Amiloride, available as the brand Midamor, is a potassium-sparing diuretic medication that helps to maintain potassium levels in patients who have considerably low potassium in the body. The medication works by impacting the kidneys to eliminate excess salt and water content but with retaining of potassium. The drug’s onset time for action is about two hours, with peak effects at about six hours. The biological half-life of this remedy is about six to nine hours.

What is Amiloride prescribed for?

The drug has many uses but is mainly administered as a remedy for managing hypertension or high Blood Pressure and congestive heart failure to help restore normal potassium levels. The medication is combined with other pills that may be required for the patient to convalesce completely.

Dosage and Administration

Amiloride is available for use in the dosage strength of 5 mg. The patient may be initiated with the drug course at a starting dose of 5 mg and then titrated to 10 mg or more based on the severity of the condition being treated.

The drug may also be combined with a diuretic for better effects. The dosage increase is made only after taking into account the electrolyte balance. Be it ascites, congestive heart failure, edema, or hypertension, the maintenance dose is standard at 5-10 mg orally once a day. Higher doses of 15-20 mg once a day are also used but not regularly.

To get the best effectiveness out of the drug, one should follow the dosing instructions as recommended by the physician. The product label would also contain information on how to take this drug.

Amiloride should be taken along with food. Do not skip doses unless the missed dose is close to the time for the next dose. Taking more than required for longer than recommended can increase the risk of side effects. The drug can cause increased urination during the initial period of treatment so it is advisable to take the last dose for the day before 6 pm.

Precautionary advice

Amiloride should not be taken by people who are taking potassium supplements, have difficulty urinating, have kidney problems, and are allergic to the active ingredients.

Certain medical problems may also become affected by taking this pill and it should be disclosed to the healthcare provider if one is pregnant, expecting to become pregnant, have any food allergies, any kidney problems, diabetic, dehydrated, have low sodium levels, and heart problems.

Drinking alcohol while on this medication can make the person feel drowsier. The elderly may be more sensitive to the ingredients in the drug.

Side Effects

The side effects that are relatively mild are headache, nausea, weakness, loss of appetite, and diarrhea. More severe symptoms that are persistent require immediate medical attention. It is important to do regular tests while on this medication. High blood potassium levels can become fatal if proper treatment is not provided for excretion of the excess potassium. Rapid heartbeat and muscle weakness are signs that the person may need additional tests to check for inconsistencies.

What drugs interact with Amiloride?

One should use caution when taking other medications along with the diuretic, particularly NSAIDs or painkillers, potassium supplements, lithium, vitamins, herbal supplements, OTC pills, and quinidine. For any further clarification, it is advisable to get them resolved with a medical practitioner.


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