Clozaril, which is the brand formulation of the drug Clozapine, belongs to a class of atypical antipsychotic medication (group of antipsychotic drugs that are used to treat psychiatric conditions). This drug is the first atypical antipsychotic and was discovered in 1960. Due to its competence the medicine is listed as the one of the Essential Medicines by the World Health Organization.

The efficacy of Clozaril is higher when compared to other antipsychotic medications used in the treatment of schizophrenia (long-term mental disorder). The medicine also decreases the rate of suicidal thoughts that arise in patients with schizophrenia and mental disorder that is characterized by abnormal thought processes and unregulated emotions (schizoaffective disorder).

What is Clozaril used for?

Clozaril is mainly used in the treatment of symptoms that arises due to schizophrenia which is a condition of mental illness that is indicated by eccentric emotions and hallucinations. The medicine is found to be effective when other antipsychotic medications have failed.

The rate of re-offending is lower and the acceptability of the drug by the patient is better. Though it is found to be very effective, it is strictly not recommended for treatment in elders suffering from dementia, a disorder characterized by behavioral problems.

The medicine has high potential in reducing the white blood cells that may lead to mortality, so the blood of the person taking this medication is supposed to be monitored on a regular basis. Hence it is better to get prescribed Clozaril after consulting a physician so you can follow a correct dosing regimen.

How to take Clozaril?

The pill has to be consumed orally and exactly as specified by the physician. The dosage regimen can be modified after 2 weeks of medication, if the prescribed dose is insufficient to bestow anticipated improvement.

The dosage of Clozaril drug is around 350mg and 400mg and it can be taken as 2 or 3 doses a day. If a person misses to take this med for a couple of days he is supposed to consult his physician immediately as his dosage may be rescheduled.

Side effects

Common side effects that happen while a person is on treatment with Clozaril medicine are

  • constipation,
  • seizures,
  • insomnia,
  • tremors,
  • bed-wetting,
  • weight gain.

Severe side effects are

  • myocarditis,
  • gastrointestinal hypomotility,
  • delusions,
  • change in libido

If anyone experience the above mentioned side effects then he/she should be treated by a physician immediately.

Interactions with other drugs

Drug interaction is possible both in branded formulation and generic Clozaril. It is advised to consult a doctor and know about the contraindications of the drug completely in order to avoid any drug interaction.

The medicines that interact with this drug are sedatives, carbamazepine, benzodiazepines and ciprofloxacin.


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