Indocin is a nonsteroidal anti-inflammatory drug that works by preventing the production of prostaglandins which is the physiologically active lipid that is found in every tissue of the body. The pill was discovered in the year 1963 and was approved by FDA in 1965 for use in the US markets.

Indocin is an effective tocolytic agent (meds that are used to suppress premature labor). By inhibiting prostaglandin in the uterus it reduces the uterine contractions in pregnant women.

Medical Uses

Indocin is primarily used to treat moderate to severe pain. As the pill prevents the production of prostaglandins it reduces swelling and pain. It is also used to treat menstrual cramps, reactive Arthritis, hypnic headaches (mild headaches that occur in people older than 63 years of age), rheumatoid arthritis, renal colic (pain due to kidney stones) and juvenile or childhood arthritis. In most cases the condition can be prevented from happening if the pill is taken in the way it has been directed.

Indocin is also helpful in the treatment of arthritis, gout and migraines. This pill is not supposed to be taken as a pain relief pill for minor aches or fever. In most cases it is used as an anti-inflammatory medication.

Dosing guide

Initially lower dose of Indocin is recommended to be taken 2 to 3 times a day. Depending on the severity of side effects the dosage strength may vary. Usually 25 mg of this pill is prescribed. Based on the results, the dosage may be increased to 50 mg upon consulting a physician but the maximum recommended dosage is 200 mg for a day. The generic version of this pill, indomethacin produces the same result as the brand one in terms of its efficacy. Treatment duration of this pill is also based on the medical condition for which the person is getting treated.

Important safety information

You should not use Indocin if you have any allergic reactions to any of its ingredients. Also do not use it if you have encountered allergic reactions to NSAIDs or to aspirin.

Do not take Indocin if you have just had heart bypass surgery or if you are going to have unless otherwise your doctor recommends you to take it.

If you are taking any other NSAID like ibuprofen presently, then refrain from using Indocin as doing so can result in severe unfavorable reactions or also in overdose.

Do not take Indocin during the last trimester of pregnancy as it can harm the unborn baby. If you are pregnant or planning to get pregnant do inform the doctor in advance.

If you are breastfeeding a child, then intimate your doctor about it. Do not nurse a newborn when you are taking this medicine.

Talk to your doctor if you are using any other herbal or pharmaceutical product or if you have any allergies with any of the substances. The drug causes dizziness so it is not advised to take this medicine with alcohol.

Before you use Indocin, discuss with your doctor if you have any of the below mentioned family history of illness:

Diabetes, mood swings, mental instability, Parkinson’s disease, Depression, fluid retention problems, kidney disease, liver disease, Asthma, heart failure, high Blood Pressure, anemia, bleeding, blood clotting, stomach ulcers, dehydration, alcoholism, smoking.

When Indocin is used in conjunction with ACE inhibitors, beta-blockers, diuretics and AR blockers, they can all have an impact on the effectiveness of the medication.

This medicine has the potential to cause dizziness and lethargy. Consuming Indocin along with alcohol and other medications can make the effect stronger.

Do not engage in any machinery work or driving as the drug can affect your judgement and reaction time to stimuli. If you have been on Indocin for a long period of time, the chances are high for you to get stomach ulcers and bleeding.

You should not take the medicine in large doses. Do not smoke or drink alcohol when you are taking Indocin.

Indocin should be taken along with meals though that will not minimize the risk of side effects. If you encounter symptoms of stomach bleeding, then you will have to consult the doctor immediately.

Side effects

Common side effects like constipation, dizziness, indigestion and headaches if occur should be reported immediately. Also if severe side effects like heart attacks, bloody urine, fainting and vaginal bleeding are found to happen, then they should be treated immediately by a physician.

Interaction with other drugs

Indocin interacts with many over-the-counter drugs and drugs that are used in the treatment of gout, rheumatoid arthritis, seizures and other drugs like aspirin and diuretics. An individual should consult a doctor to know the complete list of drugs that interact with this drug.


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