Lisinopril is a drug that belongs to the ACE (angiotensin-converting enzyme) inhibitor class. The drug is different from other ACE inhibitors, in that it is not metabolized by the liver, has tissue penetration, a long half-life, and is a hydrophilic. The drug has a biological half-life of about twelve hours.

Medical Uses

It is chiefly used as a treatment for hypertension or high blood pressure. Lisinopril may also be prescribed to improve the chances of survival after a heart attack, and in preventing kidney or eye problems in patients diagnosed with diabetes.

The dosage may be increased or decreased based on the patient’s response to treatment. The drug is not indicated for use in persons who have hereditary angioedema. Pregnant women should not take this compressed tablet as it can harm the developing fetus. Those who become pregnant while on this drug course should inform the healthcare provider immediately.

Dosing Guide

Lisinopril should be taken exactly as recommended by the physician. The dose may be adjusted according to the patient’s needs. However, it is important not to modify the dosage in any manner without the doctor’s consent.

The drug may be taken either with or without food. It is essential to drink plenty of water while in this drug course as it can dehydrate the body easily. The patient’s blood pressure and blood should be tested regularly to monitor the changes in health.

The individual should continue taking the medication for the prescribed period even if there is a general feeling of wellness as hypertension symptoms do not always show up with symptoms.


Alcohol should be avoided as it can further lower the blood pressure. Avoiding dehydration is vital as it can lead to stroke.

The patient should also inform the doctor if he or she has kidney problems, liver disease, high potassium content in the blood, and diabetes.

The drug should not be used by pregnant women as it can cause birth defects in the unborn baby. Inform your doctor and stop taking Lisinopril if you become pregnant. Effective contraceptives are recommended while on this medication.

Although it is not known if Lisinopril can pass through breast milk, it is better to inform the doctor if you are nursing a baby. It is advisable to avoid taking potassium supplements or salt substitutes unless asked to do so by your doctor. The drug can make you feel dizzy or light-headed. Avoid getting up too fast from a sitting or lying position.

Side Effects

The drug can cause common side effects like

  • Chest pain,
  • Cough,
  • Headache and
  • Dizziness

Severe symptoms that require immediate medical attention are less urination,

  • High potassium levels,
  • Kidney problems,
  • Liver diseases, and
  • Lightheadedness.

Interaction with other drugs

Keep the doctor informed if the individual is taking NSAIDs, potassium supplements, diuretics, drugs to prevent organ transplant rejection, gold injections, and lithium. The drug should not be taken along with medications containing aliskiren in patients with diabetes.

Apart from these vital drugs, the individual should also disclose if he or she is taking any vitamins, herbal supplements, any prescription pills, and over-the-counter drugs as these can also combine with the blood pressure medicine to interact dangerously.


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