Probalan is the brand name of Probenecid and belongs to a class of drugs called as Uricosurics. It is available in a tablet form. The onset time of the drug is 30 minutes and reaches its peak in 2 to 4 hours. It has a lasting period of 8 hours.
Probalan is used in treating chronic gout or gouty arthritis which is caused by high amount of uric acid in the blood. It helps the patient by removing excess uric acid from the body. This pill is very effective in treating even though it is not a cure. Gout arthritis is prevented as long as the medication is taken. Probenecid can also be taken along with certain antibiotics to treat infections.
Dosage and Administration
Probalan comes in the dosage strength of 500 mg. It can be taken by mouth with or without food. It is usually taken twice a day along with antacids as prescribed by the medical practitioner. When people use probalan, there is high chance to develop kidney stones, hence drink 8 to 10 glass of water to prevent it from forming. To make urine less acidic, the doctor may prescribe other medications like sodium bicarbonate or citrate.
Dosage of Probalan depends upon the condition as well as the patient’s response to therapy. Initially lower dose would be prescribed and it may be increased at a later point of time. After the patient is free from gout symptoms, the doctor would lower the dosage strength. This drug should not be taken when a patient is experiencing gout attack. It is essential to wait until the current attack is over and start the course of therapy.
Probalan is not a pain reliever hence take the medications that are prescribed by the physician to relieve pain from gout arthritis. This drug has a biological half-life of 2 to 6 hours.
Skin rash, gout exacerbation, diarrhea, vomiting, dizziness, drowsiness, nausea, pruritus, fever, anemia, blood urine, abnormal breathing, painful/swollen glands, unusual bleeding and nephrotic syndrome are some of the common ill effects. Get medical assistance as soon as possible. Certain medical problems can affect the use of Probalan. So discuss with the healthcare provider if the patients have kidney stones or disease, cancer, history of stomach ulcer or blood disease.
What drugs interact with Probalan?
Avibactam, Deferiprone, Doripenem, Citalopram, Methotrexate, Pegloticase and Zalcitabine are few medications that should not be taken along with Probalan. Patients should be very careful whilst taking this drug. Certain food, alcohol and tobacco would interact with the drug. However in some situations, the doctor would change the dose for the safety of the patients.