Sinequan is a prescription antidepressant medication and is the brand name for the generic formulation of Doxepin. It is not exactly known how the drug works but it helps to elevate mood levels, and is classified as a tricyclic antidepressant.

The chemical compounds in this drug are similar to other antidepressants of its class. Any person prescribed to take this drug can enjoy the therapeutic effects of this compressed tablet.

The antidepressant has peak drug effects at around three hours and a biological half-life of about seventeen hours on average.

Drug information

The drug is primarily used to treat the symptoms of anxiety, depression, manic-depressive disorder, psychiatric conditions, and insomnia. As a second-line treatment, topical versions of this Doxepin formulation are used to soothe hives on the skin.

The dosage of the oral pills depends on the intensity of the mental health problem and the patient’s response to the drug. It can be taken as multiple doses or once a day as recommended by the healthcare professional.


The dosage of the antidepressant should be taken exactly as prescribed by the doctor and after reading the instructions on the product label. It can be taken with food or in fasting.

The measure of the drug’s effectiveness can be assessed only over a period of two to three weeks. Hence, it is necessary to track any changes in symptoms and consult on the same during the next doctor’s visit.

Discontinuing the drug course on one’s own is not recommended as this can cause severe withdrawal symptoms. The antidepressant is not indicated for use in pregnant or lactating women.

Side effects

Some of the common side effects of taking Sinequan are,

  • changes in appetite,
  • headaches,
  • nausea,
  • urinary troubles,
  • vomiting,
  • unpleasant taste in the mouth,
  • drowsiness,
  • stomach troubles.

In case these symptoms are severe or there are any sudden adverse reactions, seek emergency medical assistance.

Patients diagnosed with depression and are prescribed antidepressants are at higher risk of developing suicidal ideation. Suitable help must be provided if the patient displays any kind of suicidal risk behavior.

Relative Contraindications

If the drug is taken along with other drugs that produce similar effects like drowsiness or relaxed breathing, they can intensify. It is important to disclose to the prescribing physician any other antidepressants that the person may be taking, particularly MAO inhibitors and selective serotonin reuptake inhibitors (SSRIs) as they can either increase the risk of side effects or result in toxic reactions. The waiting period of two to four weeks should be completed for the drug’s effects to wear off before taking Doxepin.


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