Tofranil is an antidepressant drug that is available as the generic formulation of Imipramine. The drug is classed as a tricyclic antidepressant of the dibenzazepine group. Tofranil works by inhibiting the reuptake of serotonin, norepinephrine, and histamine H1 receptors. These properties enable the drug to be used to treat different health conditions.

Drug information

The Tofranil antipsychotic medication is prescribed to treat a number of ailments. The various health conditions that the drug is used to treat are chronic or severe pain, withdrawal symptoms from drug abuse, depression, obsessive-compulsive disorder (OCD), panic disorder, and even ADHD is some persons.

If the depression condition is not diagnosed correctly and the drug is administered without knowledge of the same, the depression symptoms may become aggravated especially in persons who are manic depressive.

Tofranil should not be used by pregnant or nursing women, someone with a history of drug abuse or alcoholism, glaucoma, thyroid troubles, persons with major mental health problems, and those who are prone to suicidal ideation.


The typical doses of Tofranil antidepressant that are usually prescribed are 10 mg, 25 mg, and 50 mg. the efficacy of the drug varies from individual to individual and it has an average half-life of about twenty hours, though its effects may continue to be felt for longer.

Tofranil should be taken exactly as recommended by the doctor without modifying the dosage or the course duration. Reading the product label carefully will ensure that one’s doubly aware of any important information regarding the usage.

Tofranil should not be discontinued without medical assistance but with gradual dose tapering in order to prevent severe withdrawal symptoms. Operating hazardous equipment after administering the pills is not recommended. It can be taken with or without food. One should check with the physician before making any kind of adjustments to the dose.

Side effects

Potential side effects with taking Tofranil include

  • stomach ailments,
  • sensitivity to light,
  • odd taste in the mouth,
  • reduced interest in sex,
  • hives,
  • trouble urinating.

For more severe adverse reactions consult the physician immediately. Drug overdose is also dangerous and life-threatening if emergency medical attention is not given.

Relative contraindications

Persons should be aware of potential drug interactions and should disclose to the physician any drugs that they may be currently taking. Tofranil should not be combined with other antidepressants like MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) as the risk of side effects increases when they are combined.

Using blood thinners, glaucoma medication, thyroid management drugs, stimulants, and antihistamines can all interact adversely with Imipramine.

Smoking is also harmful as it decreases the efficacy of the antidepressant.


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